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Foundation Supported Research

The CHARGE Syndrome Foundation is approaching one million dollars in research grants.  2018 grant applications for scientific and clinical research are now available.

CHARGE Syndrome Foundation Scientific Research Grant Program

The CHARGE Syndrome Foundation, Inc. announces the availability of scientific research grants of up to $50,000 each.

The purpose of these grants is to promote:
a) new biomedical research into the etiology, genetic and molecular mechanisms and treatment of CHARGE syndrome or
b) new research into the medical diagnosis and treatment of CHARGE syndrome.

Both established and new investigators are encouraged to apply.  Proposals are for funding from September 1, 2018 through September 1, 2019 and may be in any area of basic, translational or epidemiological research.  Preference will be given to investigators who are new to CHARGE research and/or to new projects with clear potential to lead to future funding from other agencies. For more information, please contact info@chargesyndrome.org.

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Basic Science Research Grant Application

Dates for 2018 Basic Science Research Awards

Grants Due: June 1, 2018
Award start date: Sept 1, 2018

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2017 Research Grant Summary

 

The CHARGE Syndrome Foundation research awards began in 2012 and have been providing annual support for research ever since. The 2018 request for grant applications was released in February and grants are due to the Foundation on June 1, 2018. We expect the review process to be completed in the summer for grants to be awarded September 1, 2018.

In 2017, the Foundation received seven grant applications (three international), four of which were considered meritorious after review by experts in the field.  Each grant was reviewed by 2-3 experts, and a total of 7 people participated in the review process.  The awardees were:

  1. Anna Cariboni, University of Milan, Italy, “Dissecting the role of CHD7 and SEMA3A signalling in the control of reproduction and olfaction, which are defective in CHARGE syndrome patients.

-This grant proposes to study neurons in the brain that contribute to control of reproduction and olfaction, using mouse models of CHARGE syndrome.

  1. Judith Yanowitz, University of Pittsburgh, “Exploring the role of Chd7 as a master regulator of autophagy”

-This proposal addresses new functions for Chd7 in C.elegans, a worm that has a gene related to chd7.

  1. Daniel R. Marenda, Drexel University, “Assessing HDAC inhibition as a therapeutic strategy for CHARGE syndrome”

-This grant uses flies with mutations in kismet, the fly version of CHD7, to test whether pharmacological treatments are useful.

  1. Weijun Feng and Hai-Kun Liu, University of Heidelberg, “Modeling CHARGE syndrome using human iPSCs-derived brain organoid culture”

-In this proposal, the investigators test whether cell based models for CHARGE can be used to learn more about how neurons and supporting cells function in the absence of CHD7.

These projects span multiple animal species (worm/flies/mice/humans) using both whole organism and cell-based approaches, to understand new and exciting functions for CHD7 and related genes.  Each project benefits from existing or published data and shows high potential for ground-breaking discoveries. green-line

CHARGE Syndrome Foundation Clinical Research Grant Program:

The CHARGE Syndrome Foundation, Inc. announces the availability of clinical research grants of up to $25,000.  Most awards are anticipated to be in the range of $2,000 – $5,000. The purpose of these grants is to promote clinical research on the treatment, intervention, prevention, and support of individuals with medical, health, and behavioral issues, and their families.  Both established and new investigators are encouraged to apply.

Proposals are for funding from July 15, 2017 through July 15, 2018. Preference will be given to projects that include investigators who are new to CHARGE research and to projects with clear potential to lead to future funding from other agencies.

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Clinical Research Grant Application

Dates for 2018 Clinical Research Awards

Grants Due: April 30, 2018
Award start date: July 15, 2018

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Previous Grant Recipients Archive